The Role of JAK2 Mutation in Polycythaemia Vera in Some Iraqi Patients
Polycythaemia vera (PV) is a myeloproliferative disease that arises in a clonal haematopoietic stem cell and is characterized by increased red blood cell production that is independent of the mechanisms that normally regulate erythropoiesis. Evaluation of the role of JAK2 mutation had been carried out in polycythaemia vera in some Iraqi patients, from beginning June 2008 up to the 30 of November 2009,attending national center of hematology for research and treatment . Thirty two patients have been included with age range of 30-66years and ten apparently healthy control group with age range of 32-55 years. Results revealed that polycythemic patients had mean age of (50.41 ±1.71). The molecular study using amplification refractory mutation ,has clarified that (90.6%) of patients with polycythaemia vera had JAK2 mutation .According to the above results to introduce JAK2 mutation test as part of routine work in suspected patients with Polycythaemia vera.