Isochromosome 6(p) is a rare chromosomal aberration in Acute Lymphoblastic Leukemia: A case report

  • Noor Hashim Ismail

Abstract

Cytogenetic analysis using G- banding technique was performed on bone marrow cells from a 22-year-old female who was diagnosed with Acute Lymphoblastic Leukemia . The chromosomal analysis showed a complex karyotype which included the Isochromosome 6(p) in 16 metaphases (16%) of 97 total metaphases studied . This finding suggests a strong selective pressure for loss of heterozygosity of genes located on 6q , and is in keeping with the hypothesis that one or more tumor suppressor genes might be located on the long arm of chromosome 6 . Moreover, trisomy (or tebasomy) for the short arm of chromosome 6, due to the isochromosome formation , indicating also a possible role for amplification of genes located on 6p in tumor progression in this case of acute lymphoblastic leukemia

Published
2018-01-14
How to Cite
ISMAIL, Noor Hashim. Isochromosome 6(p) is a rare chromosomal aberration in Acute Lymphoblastic Leukemia: A case report. Iraqi Journal of Cancer and Medical Genetics, [S.l.], v. 5, n. 2, jan. 2018. ISSN 2078-6123. Available at: <http://ijcmg.uomustansiriyah.edu.iq/index.php/ijcmg/article/view/89>. Date accessed: 21 oct. 2020.
Section
Articles

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