Cytotoxic Activity of Taraxacum officinale Ethanolic Plant Extract against Human Breast Cancer (MCF-7) Cells and Human Hepatic (WRL-68) Cells

Abstract

Taraxacum officinale (Dandelion) represent a potentially novel non-toxic alternative to conventional cancer therapy toward
many cancers particularly breast cancer.
This study was conducted to detect the cytotoxic activity of T. officinale whole plant ethanolic extract on human breast cancer
(MCF-7) cells in vitro compared to human hepatic (WRL-68) cells using MTT assay.
Graphed 6 prism program including non-linear regression with one –way ANOVA followed by Dennett’s multiple comparison
test to obtain data represent the mean+ SD.
The results revealed high toxicity of the extract against MCF-7 cells with IC50 (190.5 μg.ml-1) and showed high-reduced
activity toward WRL-68 cells with high IC50 value while the lowest viability (21.57±5.322) appeared in MCF-7 cells under
treatment with 400 μg.ml-1 compared with high viability in WRL-68 cells.
The study concluded that T. officinale extract has a valuable source of anticancer drugs with safe and selective activity on
cancer cells in comparison to human normal cells.