Relationship between blood lead levels and cytogenotoxic effects in human exposed to diesel exhaust
Diesel exhaust (DE) is a mixture of hundreds organic and inorganic compounds, several of them are cytogenotoxic. This way, the aim of this study was to indicate the relationship between blood lead level and the exposure to cytogenotoxic constituents of DE. Blood samples were collected from 80 nonsmoker healthy men. Sixty of them were exposed directly to DE and the others were negative control. Exposure metrics included blood lead levels (Blls) while cytogenotoxic effects of DE were investigated by using micronucleus assay (MN), sister chromatid exchange assay (SCE) and comet assay. The results showed that the means of Blls in exposed workers to DE (47.40 – 49.50) µg/dl significantly higher (P <0.01) than mean of Blls in control gruop (15.75) µg/dl. When Blls range from 60 to 80 µg/dl , the cytogenotoxic effects were significantly higher (P <0.01) than others Blls groups. So that BLL it can be indictor to exposure to DE which have cytogenotoxic effects on human.