CTLA4 gene polymorphisms associated with insulindependent diabetes mellitus (IDDM) type I in Iraqi population

  • Najwa Sh. Ahmed

Abstract

This study was correlated to evaluate polymorphisms in CTLA4 associated with insulin-dependent diabetes mellitus in a Iraqi population. Blood samples were collected from 40 patient (4-25 years) from 1/6/2010- 1/2/2011, isolation of DNA were done and PCR was performed using primer for CTLA4 gene. The result shows that 31 patients have mutation in 49 position A/G polymorphism in exon 1 of CTLA4 by using BstEII enzyme. There is a highly significant correlation between diabetes and incidence of A/G 49 position in exon 1 of CTLA4 gene (X2 = 32.1, P>0.05), the conclusion is that there is enough evidence to support the claim that diabetes is related to A/G 49 transition mutation

Published
2018-01-14
How to Cite
AHMED, Najwa Sh.. CTLA4 gene polymorphisms associated with insulindependent diabetes mellitus (IDDM) type I in Iraqi population. Iraqi Journal of Cancer and Medical Genetics, [S.l.], v. 5, n. 2, jan. 2018. ISSN 2078-6123. Available at: <http://ijcmg.uomustansiriyah.edu.iq/index.php/ijcmg/article/view/84>. Date accessed: 09 aug. 2020.
Section
Articles

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