Cytotoxic Effect of Peganum harmala L. Extract and Induction of Apoptosis on Cancerous Cell Line

Abstract

The methanol extract of Peganum harmala L. was tested in vitro on the cancercell line Hep-2 (human
laryngeal Carcinoma Cell, the results revealed dose- dependant significant differences, there was increasing cytotoxic effect at concentrations 156-10000 µg/ml. At the first 24 hrs. of exposure time, and with no significant differences on all period time (24, 48 and 72 hrs.). And the results showed that was increasing on apoptotic process after treated with methanol extract of P. harmala to repairing the damage of the cell and induction of cell death compared with control (not treated) on concentration 156 and 312 µg/ml.