Oxidative Stress and Antioxidant Status in Colorectal Cancer and Healthy Subject

Abstract

Background: Total antioxidant status (TAO), superoxide dismutase (SOD) and Catalase (CAT) are antioxidant defensive enzymes that are catalyze the reduction of reactive oxygen species (ROS) to non harmful substance. Aim: The study focuses on the serum super oxide dismutase enzyme level, CAT level and total antioxidant status in colorectal cancer patients, which result due to an imbalance between aggressive and defensive factors. Materials and Methods: the study included 40 patients and 20 healthy individuals for comparative analysis were considered for the present study. (TAO), serum (SOD) and (CAT) levels of each individual were performed. Results: Statistical analysis of serum antioxidant enzymes level and antioxidant status revealed a significant increase in SOD, CAT of patients group (p.≥0.05), and (P.≥0.01) respectively.
The TAO was significant increase (p.≥0.001). The increasing preponderance of serum SOD, CAT levels and the TAO can be explained on the basis of alteration on enzymes activity, which may lead to disturbance in homeostasis of antioxidant/oxidant balance... Conclusions: TAO, Catalase and Superoxide dismutase enzyme used a biomarker of enzymatic alteration in different diseases including cancer.