Evaluating the Level of Some Antioxidants and C-Reactive Activators Protein in a Sample of Iraqi Women with Breast Cancer

Level of Antioxidants in Women with Breast Cancer

Abstract

One of the key causes of cancer is the detrimental effect of reactive oxygen species on DNA repair mechanisms. The present study aims to describe the function of oxidative stress in boosting breast cancer and to point out the potential defense role of antioxidants and some trace elements. In addition, it is to estimate the concentration of C - C-reactive protein (CRP), a marker of inflammation. Methods: This study was carried out at the Al-Anbar Oncology Center between January and June 2023. Sixty women with breast cancer and forty healthy women were recruited into this study. Serum antioxidant activity, such as superoxide dismutase. (SOD), Catalase (CAT), vitamin D3, vitamin B12, and some essential chemical elements such as zinc (Zn), copper (Cu), iron (Fe), and selenium (Se). CRP concentration was assessed. Results: The results reveal a significant (P<0.05) decrease in serum antioxidant concentrations such as SOD, CAT, vitamin D3, and vitamin B12 concentration in serum blood of women with breast cancer compared to the apparently healthy women group. The results showed a significant increase (p <0.05) in the CRP concentration of the blood serum of women with breast cancer compared to the healthy women group. The results showed a significant decrease (p <0.05) in the concentration of Zn, Cu and Fe in the serum blood of women with breast cancer compared to the healthy women group. Additionally, there was a significant increase (p <0.05) in Se concentration in serum blood in women with breast cancer. The percentage of breast cancer is lower in urban areas than in rural areas. Conclusions Women with breast cancer showed high levels of oxidative stress as evidenced by increased oxidant markers and decreased antioxidant markers.