Genotype Distribution of Angiotensin I- Converting Enzyme in Iraqi Arab Population

Authors

  • Salwa J. Al-Awadi Genetic Engineering and Biotechnology Institute-Baghdad University.
  • Abdulameer M. Ghareeb Genetic Engineering and Biotechnology Institute-Baghdad University
  • Abdulrahmahman A. Oleiwi Genetic Engineering and Biotechnology Institute-Baghdad University
  • Wisam H. Salo Genetic Engineering and Biotechnology Institute-Baghdad University.
  • Ali Imad Mohmmad Moner Genetic Engineering and Biotechnology Institute-Baghdad University.

DOI:

https://doi.org/10.29409/ijcmg.v4i2.63

Keywords:

ACE (angiotensin-converting enzyme) genotype, ACE polymorphism.

Abstract

The angiotensin-converting enzyme (ACE) gene in humans has an insertion-deletion (I/D) polymorphic which produce three allelic variants: II, ID & DD that associated with population relativity and relation with many genetic disease. The polymorphisms of ACE gene were investigated using polymerase chain reaction. The results showed a high frequency of the DD allele among the Iraqi Arab populations (50%), which is similar to those obtained from previous studies for Arab populations. More ever the distribution of ACE genotype among male and female (n= 100, 53male & 47 female) showed DD: 47.17%, II: 22.6% & ID: 30.19% in the male group and DD: 40.43%, II: 17.02% & ID42.55:% in the female group. Significant association of hypertension & diabetic with D allele of the ACE gene has been in Iraqi Arab population.

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Published

2011-12-01

Issue

Vol. 4 No. 2 (2011)

Section

Cancer Research

License

Copyright (c) 2011 Iraqi Journal of Cancer and Medical Genetics

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.