Distribution of ABO Blood Groups in Iraqi Samples of Leukemia and Lymphomas


  • Ali H. Ad’hiah Tropical-Biological Research Unit, College of Science, University of Baghdad
  • Ekhlass N. Ali Department of Biology, College of Science, Al-Mustansiryiah University




ABO blood groups, Acute lymphoblastic leukemia, Chronic lymphocytic leukemia, Acute myeloid leukemia, Chronic myeloid leukemia, Hodgkin’s lymphoma, Non-Hodgkin’s lymphoma


The records of Hematological Diseases Unit at Baghdad Teaching Hospitals and National Center for Research and Treatment of Hematological Diseases (Al-Mustansiryiah University) were inspected for leukemia and lymphoma patients who were diagnosed and treated during the period 2008-2010, and their ABO blood groups were also obtained. The patients were distributed as 281 ALL, 128 CLL, 192 AML, 208 CML, 114 HDL (Hodgkin’s lymphoma) and 197 NHL (non-Hodgkin’s lymphoma). In addition, 595 blood donors were also included and considered as controls. Testing the goodness of fit for ABO blood group allele and phenotype frequencies showed a good agreement with Hardy-Weinberg equilibrium (HWE) in controls and in ALL, CLL and HDL patients. In contrast, a significant corrected deviation was observed in CML (Pc = 0.04) and NHL (Pc = 2.3 x 10-6) patients. A further group of patients (CLL) also showed a significant deviation from HWE, but the difference was significant before correction (P = 0.05; Pc = 0.20). A further analysis of ABO blood group alleles revealed that their estimated numbers and frequencies varied between patients and controls, but a significant difference was recorded in CLL, CML and NHL patients. The allele I*A was significantly decreased in CLL (32.0 vs. 41.5%) and CML (28.8 vs. 41.5%) patients as compared with controls, but a corrected significant level was only observed in CML patients (Pc = 0.003). In NHL patients, the allele I*B was significantly decreased and the difference remain significant after correction (25.9 vs. 34.1; Pc = 0.03). These findings suggest a role of blood group phenotypes and alleles in the etiology of hematological malignancies






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