Polymorphism of Rh(D,C,c,E,e) Blood Group System in Beta-thalassemia

Abstract

The Rh(D,C,c,E,e) were typed in a sample consisted of 378 individuals, one hundred of them present the control whereas the remaining 278 individuals were affected by β-thalassemia. The last group was divided into three types; 156 of individuals affected with major thalassemia, 66 of individuals affected with intermediate thalassemia and 56 of individuals affected with minor thalassemia (carriers).
The aim of the present study is to find any genetic variation in the distribution of Rh blood group system between thalassemia and control groups. The various comparisons lead to a significant difference in Rh group for β-thalassemia and all its subtypes except the minor one, because of the decrease in resistant phenotype CCDee and increase in CcDEe phenotype. It is clear, the importance of the Rh blood group since it can be considered as a source for detecting the risk of inheritance for β-thalassemia and / or the probability of its expression. It can be used with the other laboratory tests in genetic counseling. This study, recommended to do more studies about the other blood groups in order to know about its phenotypic frequencies between healthy and disease samples