Redox status in saliva and serum of Iraqi patients in a pre-malignant and early malignant stage of breast tumors

الملخص

Breast cancer, as is commonly assumed, one of the most diagnosed kind of cancer is a multifactorial disease, its exact cause is still unknown. It is considered the second killer cancer among women. The present study participants were Iraqi women patients in pre-malignant and malignant (n=59) women with breast tumors as well as age matched healthy Iraqi women (n=27). This study aimed to evaluate the redox status upon transformation from premalignant (benign) to malignant stage of breast cancer by evaluating the saliva-blood correlation to look for the possibility using saliva as alternative fluid for diagnosis of the tumor stages. This was achieved by measuring the [total oxidant status level (TOS), total antioxidant status level (TAS), and oxidative stress index level(OSI). (TOS) and (TAS) were determined in saliva and serum fluid samples from all participants using colorimetric methods, while the oxidative stress index (OSI) was calculated. The results obtained from the study showed that the P value ≤ 0.01 significantly increased the measured [TOS] level and the calculated [OSI] level in saliva and serum fluid samples in contrast significantly decreased the P value ≤ 0.01 in the [TAS] level in both types of fluids of the patient groups compared to that of the healthy control group. Similar results were obtained when the values of these parameters were compared in both samples (serum and saliva) samples were compared between the patient groups in both breast tumors (Pre-malignant& malignant).