The Relationship Between Bcl-2, and P53 Protiens in transitional Cell Carcinoma of the Bladder

الملخص

Transitional cell carcinoma (TCC) of the bladder in patients has historically a favorable prognosis. Bcl-2 and p53 genes are implicated in cell cycle regulation with roles on programmed cell death. Presence of nuclear accumulation of p53 and cytoplasmic accumulation of bcl-2 were proposed to confer a growth advantage to tumor cells. In this study, we investigated the roles of p53 and bcl-2 as prognostic factors in TCC of bladder. Method: Investigated 25 patients with transitional cell carcinoma (TCC) and 27 patients with cystitis (control group) for the expression of Bcl-2 and P53 by immunohistochemical staining with specific monoclonal antibodies. Results: Bcl-2 was significantly expressed in TCC compared to those with cystitis (control). Moreover, P53 was significantly expressed in TCC compared to those with cystitis (control). A significant positive correlation between these two parameters in Tcc. Conclusions: These observations detect that increased the expression of Bcl-2 and P53 in TCC play a potential role in the development of bladder cancer.