Genotype Distribution of Angiotensin I- Converting Enzyme in Iraqi Arab Population

Salwa J. Al-Awadi; Abdulameer M. Ghareeb; Abdulrahmahman A. Oleiwi; Wisam H. Salo; Ali Imad Mohmmad Moner

doi:10.29409/ijcmg.v4i2.63

المؤلفون

Salwa J. Al-Awadi Genetic Engineering and Biotechnology Institute-Baghdad University.
Abdulameer M. Ghareeb Genetic Engineering and Biotechnology Institute-Baghdad University
Abdulrahmahman A. Oleiwi Genetic Engineering and Biotechnology Institute-Baghdad University
Wisam H. Salo Genetic Engineering and Biotechnology Institute-Baghdad University.
Ali Imad Mohmmad Moner Genetic Engineering and Biotechnology Institute-Baghdad University.

DOI:

https://doi.org/10.29409/ijcmg.v4i2.63

الكلمات المفتاحية:

ACE (angiotensin-converting enzyme) genotype، ACE polymorphism.

الملخص

The angiotensin-converting enzyme (ACE) gene in humans has an insertion-deletion (I/D) polymorphic which produce three allelic variants: II, ID & DD that associated with population relativity and relation with many genetic disease. The polymorphisms of ACE gene were investigated using polymerase chain reaction. The results showed a high frequency of the DD allele among the Iraqi Arab populations (50%), which is similar to those obtained from previous studies for Arab populations. More ever the distribution of ACE genotype among male and female (n= 100, 53male & 47 female) showed DD: 47.17%, II: 22.6% & ID: 30.19% in the male group and DD: 40.43%, II: 17.02% & ID42.55:% in the female group. Significant association of hypertension & diabetic with D allele of the ACE gene has been in Iraqi Arab population.