Effect of Pomegranate extract on P53 expression in Cancer Cell line (Hep-2)

  • Zaynab S. Abdul-Gany


Background: Pomegranate (Punica granatum) fruits are widely consumed as juice. The potent antioxidant and antiatherosclerotic activities of pomegranate are attributed to its polyphenols. Aim: Pomegranate extract were evaluated for in vitro cytotoxic and its effect on the level of p53 in Hep2 (Human larynx epidermal carcinoma). Methods: Aqueous extraction of pomegranate was prepared and in vitro cytotoxicity and amount of p53 was evaluated on cancer cell line Hep2 (Human larynx epidermal carcinoma). Results: The study showed that the pomegranate extract has greatest antiproliferative activity by inhibition proliferation from 13% to 73.9%, at 10 µg/ml and 24 hr period of exposure. Also, the study showed significant decrease of p53 in treated group in comparison to control. Conclusions: According to the in vitro antiproliferative activity, inhibition of p53 expression pomegramate extracts may be possess a potent anticancer activity.

How to Cite
ABDUL-GANY, Zaynab S.. Effect of Pomegranate extract on P53 expression in Cancer Cell line (Hep-2). Iraqi Journal of Cancer and Medical Genetics, [S.l.], v. 4, n. 1, jan. 2018. ISSN 2078-6123. Available at: <http://ijcmg.uomustansiriyah.edu.iq/index.php/ijcmg/article/view/52>. Date accessed: 09 aug. 2020.

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