Anti-tumor effect of Water and Alcoholic Extracts of Mushroom Agaricus bisporus against murine mammary adenocarcinoma- implanted mice

Abstract

This research was designed to study the effect of water and alcoholic crude extracts of Agaricus bisporus in vivo.
Therapeutic effect of both extracts was studied in murine mammary adenocarc- inoma- implanted mice after (I.P) administration of watery extract at concentrations of (333.3, 500, 666.6 mg/kg) and alcoholic extract at concentrations of (500, 1000, 1500 mg/kg) for 30 days alternatively.
The results revealed significant reduction in the tumor volume weather in those treated with watery extract 87.10%, or those treated with alcoholic extract 87.98%, particularly at the concentration of 666.6 mg/kg and 500 mg/kg respectively.
Histopathological study showed necrosis and infiltration of inflammatory cells within fibrous encapsulated tumor mass.